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Multifocal electroretinogram in adults and children with myopia.

Luu CD, Lau AM, Lee SY

Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore. seri_chiluu@snec.com.sg

OBJECTIVE: To determine the correlation between multifocal electroretinogram (mfERG) parameters and the severity of myopia in adults and children. DESIGN: Observational study. METHODS: Multifocal electroretinograms were recorded using the VERIS system from randomly selected eyes of 104 children and 31 adults with various degrees of myopia. Dawson, Trick, and Litzkow fiber electrodes were used and the pupil was dilated with 1% tropicamide. Subjective refraction was performed under cycloplegia and axial length measurement was determined by A-scan ultrasonography. The N1 (first negative trough), P1 (first positive peak), and N2 (second negative trough) components of the first-order kernel response of the mfERG were measured and correlated with the refractive data. MAIN OUTCOME MEASURES: First-order kernel mfERG responses. RESULTS: The N1, P1, and N2 amplitudes were significantly correlated with the severity of myopia in adult subjects (N1, r = 0.591, P = .001; P1, r = 0.682, P<.001; N2, r = 0.732, P<.001). The response amplitudes of N1, P1, and N2 decreased as the dioptric power of myopia increased. However, there were no significant correlations found between N1 (r = 0.073, P = .30), P1 (r = 0.071, P = .31), and N2 (r = 0.052, P = .46) amplitudes and the severity of myopia in children. The severity of myopia was also significantly correlated with N1 (r = -0.750, P<.001), P1 (r = -0.769, P<.001), and N2 (r = -0.664, P<.001) implicit times in adults with myopia, however, only the P1 (r = -0.166, P = .02) implicit time was significantly correlated with children with myopia. CONCLUSIONS: There is a significant correlation between the refractive error and mfERG amplitude in adults with myopia; however, such a relationship is absent in children with myopia. These findings suggest that the severity of myopia has little influence on the ERG amplitude, at least in children.

Published 14 March 2006 in Arch Ophthalmol, 124(3): 328-34.
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